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Volume 52, Number 1, February 2019

Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events 


Shang-Yi Lin, Yi-Wen Chiu, Po-Liang Lu, Shang-Jyh Hwang, Tun-Chieh Chen, Min-Han Hsieh, Yen-Hsu Chen


 

Background and purpose: 

The consequences of once-weekly rifapentine plus isoniazid for 3 months (3HP) against latent tuberculosis infections in hemodialysis patients have not been studied before. This is the first study to evaluate the safety and tolerability of 3HP in this population and revealed a completion rate of 65.4%. The therapy was not associated with hepatotoxicity, but with high rates of adverse events (69.2%). 



 

Key words:

Rifapentine3HPLatent tuberculosisLTBIHemodialysis