Changes in minimum inhibitory concentration of levofloxacin for Escherichia coli strains isolated from urine samples in mainland China, 2004 to 2014
Yun Li, Bo Zheng, Feng Xue, Sai-Nan Zhu, Yuan Lyu
Corresponding author:
Bo Zheng, Corresponding author. Institute of Clinical Pharmacology, Peking University First Hospital, Number 8, Xishiku Street, Xicheng District, 100034 Beijing, China.
Background and purpose:
Eschrichia coli urinary isolates were collected from 20 Chinese hospitals during five 1-year periods from 2004 to 2014. The susceptibility of E. coli to levofloxacin has remained stable during the past 11 years, and 90% of strains had minimum inhibitory concentrations of ≤32 mg/L. The urine-specific susceptibility breakpoints for levofloxacin should be reset based on more relevant clinical studies and the current pharmacokinetic/pharmacodynamic considerations in this field.
Key words:
Escherichia coli, levofloxacin, susceptibility, urinary tract infection
Comments
Respond to this article