Changes in minimum inhibitory concentration of levofloxacin for Escherichia coli strains isolated from urine samples in mainland China, 2004 to 2014 

Yun Li, Bo Zheng, Feng Xue, Sai-Nan Zhu, Yuan Lyu

Bo Zheng, Corresponding author. Institute of Clinical Pharmacology, Peking University First Hospital, Number 8, Xishiku Street, Xicheng District, 100034 Beijing, China. 

Eschrichia coli urinary isolates were collected from 20 Chinese hospitals during five 1-year periods from 2004 to 2014. The susceptibility of E. coli to levofloxacin has remained stable during the past 11 years, and 90% of strains had minimum inhibitory concentrations of ≤32 mg/L. The urine-specific susceptibility breakpoints for levofloxacin should be reset based on more relevant clinical studies and the current pharmacokinetic/pharmacodynamic considerations in this field. 

Escherichia coli, levofloxacin, susceptibility, urinary tract infection