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Volume 50, Number 3, June 2017

Antimicrobial susceptibility to β-lactam antibiotics and production of BRO β-lactamase in clinical isolates of Moraxella catarrhalis from a Japanese hospital 

Kageto Yamada, Katsumi Arai, Ryoichi Saito


Corresponding author:

Kaogeto Yamda, Corresponding author. Department of Clinical Laboratory, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital, 33-1 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. 


Background and purpose: 

We investigated BRO-β-lactamase production of Moraxella catarrhalis isolates and its antimicrobial susceptibility to β-lactams. Of the 233 isolates, 232 were BRO producers and 224 were BRO-1 producers. Four isolates exhibited elevated ceftriaxone minimum inhibitory concentration (2 μg/mL) and different pulsed-field gel electrophoresis patterns and we expect this number to increase in the near future. 


Key words:

antimicrobial susceptibility, β-lactam, BRO β-lactamase, ceftriaxone, Moraxella catarrhalis