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Volume 50, Number 4, August 2017

Safety and efficacy of anti-influenza drugs, intravenous peramivir against influenza virus infection in elderly patients with underlying disease 


Kazufumi Takamatsu, Satoshi Marumo, Motonari Fukui, Atsuko Hata


 

Corresponding author:

Atsuko Hata, Corresponding author. Department of Infectious Diseases, Department of Infection Control, Department of Pediatrics, Division of Infectious Diseases, Tazuke Kofukai Medical Research Institute Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Fax: +81 6 6312 8867. 



 

Background and purpose: 

We retrospectively analyzed data of 38 elderly patients, each with an underlying disease, to evaluate peramivir safety and efficacy. Six patients (15.8%) experienced adverse events, all tolerated. Median time from administration until the return to normal temperatures was 31.5 h (95% CI: 22.4–40.6). Results confirm intravenous peramivir's usefulness. 



 

Key words:

Aging, Antiviral drugs, Geriatrics, Gerontology, High-risk patient, Neuraminidase inhibitor