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Volume 49, Number 6, December 2016

Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis 

Kiran I. Masood, Shahid Pervez, Martin E. Rottenberg, Beena Umar, Zahra Hasan


Corresponding author:

Zahra Hasan 


Background and purpose: 

We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas. 


Key words:

caseous necrosis, granuloma, suppressor of cytokine signaling-1, tuberculous lymphadenitis