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Volume 49, Number 6, December 2016

Anti-Mycobacterium tuberculosis activity of antituberculosis drugs and amoxicillin/clavulanate combination
 


Aline Daniele Furlan Pagliotto, Katiany Rizzieri Caleffi-Ferracioli, Mariana Aparecida Lopes, Vanessa Pietrowski Baldin, Clarice Queico Fujimura Leite, Fernando Rogério Pavan, Regiane Bertin de Lima Scodro, Vera Lúcia Dias Siqueira, Rosilene Fressatti Cardoso


 

Corresponding author:

Rosilene Fressatti Cardoso 



 

Background and purpose: 

We report the in vitro drugs interaction by the resazurin drugs combination microtiter assay (REDCA) of amoxicillin (AMO)/clavulanate (CLAV) with isoniazid (INH), ethambutol (EMB), and rifampicin (RIF) against susceptible and resistant Mycobacterium tuberculosis isolates. The addition of AMO/CLAV to classical antituberculosis drugs should be explored as a promising alternative for the treatment of resistant tuberculosis (TB). 



 

Key words:

amoxicillin/clavulanate, checkerboard, Mycobacterium tuberculosis, synergism, tuberculosis