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Volume 49, Number 6, December 2016

Impact of IL-22 gene polymorphism on human immunodeficiency virus infection in Han Chinese patients 


Jun Hu, Yi Li, Lin Chen, Zhengrong Yang, Guanglu Zhao, Yushu Wang, Jinquan Cheng, Jin Zhao, Ying Peng


 

Corresponding author:

Ying Peng 



 

Background and purpose: 

To analyze the polymorphism of the IL-22 gene in Han Chinese patients and to evaluate the influence of IL-22 polymorphism on human immunodeficiency virus (HIV) infection. 



 

Methods:

IL-22 gene polymorphism was analyzed in 73 blood samples from healthy participants. The influence of the genotype and allele distribution of three single nucleotide polymorphisms (rs2227484, rs2227485, and rs2227513) of IL-22 on HIV infection was evaluated in 619 HIV seropositive patients and 619 healthy controls. To determine the association between the rs2227513 genotype and IL-22 levels in plasma, we randomly selected 29 HIV seropositive blood samples and 15 healthy blood samples and measured the levels of IL-22. 



 

Results:

Nine single nucleotide polymorphism loci of the IL-22 gene were found (rs2227484, rs2227485, rs2227491, rs2227508, rs2227513, rs1179249, rs1179250, rs1179251, and rs1182844). Stratified analysis (by sex) showed a higher association of HIV infection and the A/G genotype and G allele at rs2227513 in women, but not in men (A/G genotype odds ratio = 5.24, 95% confidence interval = 1.13–24.27; allele G odds ratio = 5.27, 95% confidence interval 1.15–24.23). The rs2227513 A/G genotype was also associated with significantly higher levels of plasma IL-22, regardless of whether the patient was HIV seropositive or seronegative. 



 

Conclusion:

Our results suggest that IL-22 production in blood might act as a pathogenic factor in HIV infection. 



 

Key words:

Han Chinese, haplotype, HIV infection, IL-22 gene polymorphism