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Volume 49, Number 5, October 2016

Myeloperoxidase genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children 


Ken-Pen Weng, Kai-Sheng Hsieh, Shih-Hui Huang, Huang-Wei Wu, Jen-Hung Chien, Chu-Chuan Lin, Chia-Wan Tang, Shan-Fu Ou, Sin-Jhih Huang, Luo-Ping Ger


 

Corresponding author:

Corresponding authors. Ken-Pen Weng, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, 813 Kaohsiung, Taiwan, ROC. 



 

Background and purpose: 

The aim of this study was to investigate the myeloperoxidase (MPO) -463G>A polymorphism in Kawasaki disease (KD) patients, and the relationship between gene polymorphism and MPO levels.

 



 

Methods:

A total of 334 KD children and 492 sex-matched controls were assayed for polymorphism analysis. TaqMan assays were used for genotyping. MPO was measured in 37 KD patients and 42 febrile controls. 



 

Results:

A significant linear trend of KD risk was found to be related to the G/G genotype (plinear trend = 0.032). The combined genotypes (G/A and A/A) of MPO -463G>A were associated with a significantly decreased KD risk compared to the G/G genotype [adjusted odds ratios (AOR) = 0.71, 95% confidence interval (CI): 0.52–0.99, p = 0.040]. In addition, KD patients with A allele were associated with a significantly decreased KD risk as compared to those with G allele (AOR = 0.73, 95% CI: 0.54–0.98, p = 0.033). MPO levels were significantly elevated in KD patients in preintravenous immunoglobulin (pre-IVIG) stage compared to febrile controls (p = 0.002). KD patients in pre-IVIG stage had significantly higher MPO levels than febrile controls in terms of G/G genotype (p = 0.003) and G allele (p < 0.001). KD patients with A allele had significantly lower MPO levels than those with G allele in post-IVIG acute stage (p = 0.042). However, there was no significant difference of individual MPO change for KD patients from pre- to post-IVIG stage in terms of genotypes (p = 0.837) or alleles (p = 0.631). 



 

Conclusion:

Our results suggest that G allele of MPO -463G>A polymorphism is a potential genetic marker for KD risk in Taiwanese children. 



 

Key words:

Kawasaki disease, myeloperoxidase, polymorphism