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Volume 49, Number 2, April 2016

Sepsis is a more important risk factor for cytomegalovirus colitis in human-immunodeficiency virus-negative adults with chronic kidney disease

Ding-Ek Toh, Fat-Moon Suk


Corresponding author:

Corresponding author. Fa-Moon Suk, Division of Gastroenterology, Department of Internal Medicine, Wan Fang Medical Center, Taipei Medical University, Number 111, Section 3, Hsing Long Road, Taipei 116, Taiwan. 


Background and purpose: 

We read with great interest the article by Chen et al1 in the Journal of Microbiology, Immunology and Infection. The authors reported that cytomegalovirus (CMV) disease may occur in chronic kidney disease patients without overt immunodeficiency, and that the gastrointestinal tract, especially the colon, has been recognized as the most common site. They also mentioned that chronic kidney disease is a CMV-prone condition, especially in patients with end-stage renal disease. A cumulative of risk factors have a greater risk of CMV reactivation, and sepsis has an extra strong additive value for risk factor.