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Volume 49, Number 2, April 2016

Simultaneous cryptococcal and tuberculous meningitis in a patient with systemic lupus erythematosus 

Bilgul Mete, Nese Saltoglu, Ersin Vanli, Cigdem Ozkara, Ferhat Arslan, Ali Mert, Resat Ozaras, Fehmi Tabak, Recep Ozturk


Corresponding author:

Corresponding author. Bilgul Mete, Department of Infectious Diseases and Clinical Microbiology, Istanbul University, Cerrahpasa Medical Faculty, Kocamustafapaşa, 34098 Istanbul, Turkey. 


Background and purpose: 

Simultaneous central nervous system (CNS) infection with Cryptococcus and tuberculosis (TB) is very rare. Despite improved therapeutic options, treatment of CNS cryptococcosis is still difficult and needs invasive treatment modalities, such as intrathecal or intraventricular amphotericin B, in refractory cases. We describe a patient with systemic lupus erythematosus diagnosed with simultaneous cryptococcal and TB meningitis who had a poor response to intravenous liposomal amphotericin B and fluconazole, but was successfully treated with intraventricular amphotericin B, in addition to anti-TB therapy. 


Key words:

Cryptococcus, Intraventricular amphotericin B, Meningitis, Tuberculosis