Trichosporon asahii sepsis in a patient with pediatric malignancy
Aslinur Ozkaya-Parlakay, Eda Karadag-Oncel, Ali Bulent Cengiz, Ates Kara, Atilla Yigit, Safak Gucer, Deniz Gur
Corresponding author. Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Sihhiye 06100, Ankara, Turkey
Background and purpose:
Trichosporon asahii is a rare opportunistic infection, especially in children, causing a life-threatening fungal infection underlying hematologic malignancies. Predisposing factors for infection with this pathogen are immunodeficiency including underlying malignancy, organ transplantation, extensive burns, human immunodeficiency virus infection, corticosteroid therapy, prosthetic valve surgery, and peritoneal dialysis. In the literature, a breakthrough under caspofungin, micafungin therapy is reported. In this article we report on a 16-year-old patient with Ewing sarcoma who had T. asahii sepsis. The patient died although he had been receiving caspofungin for less than 3 months and amphotericin B therapy for 3 days. A postmortem study of conchal tissues revealed T. asahii and mucormycosis histopathologically, and blood culture grew T. asahii.
Child, Sepsis, Trichosporon asahii