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Volume 49, Number 1, February 2016

Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates 

Pak-Leung Ho, Lai-Ming Leung, Kin-Hung Chow, Eileen L. Lai, Wai-U. Lo, Tak-Keung Ng

Received: February 18, 2016    Revised: February 18, 2016    Accepted: February 18, 2016   


Corresponding author:

Pak-Leung Ho
Corresponding author. Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong, People's Republic of China. 


Background and purpose: 

Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II, 12.2% had aac(6′)-Ib/Ib-cr, and 5.4% had the methylase genes (rmtB, armA). Aminoglycoside-resistant isolates with aac(′)-Ib/Ib-cr, rmtB, and armA often had coresistance to multiple other antibiotics. 


Key words:

aminoglycoside resistance, molecular epidemiology, multidrug resistance