Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates
Pak-Leung Ho, Lai-Ming Leung, Kin-Hung Chow, Eileen L. Lai, Wai-U. Lo, Tak-Keung Ng
Received: February 18, 2016 Revised: February 18, 2016 Accepted: February 18, 2016
Corresponding author. Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong, People's Republic of China.
Background and purpose:
Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II, 12.2% had aac(6′)-Ib/Ib-cr, and 5.4% had the methylase genes (rmtB, armA). Aminoglycoside-resistant isolates with aac(′)-Ib/Ib-cr, rmtB, and armA often had coresistance to multiple other antibiotics.
aminoglycoside resistance, molecular epidemiology, multidrug resistance