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Volume 48, Number 4, August 2015

Cryptococcus neoformans in sputum and lung aspiration cytology smears 

I-Shiow Jan, Wern-Cherng Cheng, Shyh-Chyi Lo, Ming-Hsiang Weng, Li-Na Lee

Received: February 26, 2014    Revised: February 26, 2014    Accepted: February 26, 2014   


Corresponding author:

Li-Na Lee
Corresponding author. Department of Laboratory Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan. 


Background and purpose: 

Cytology, both exfoliative and aspiration cytology, may play a role in the detection of causative microorganisms in immune-competent and -compromized patients. Cryptococcus neoformans (C. neoformans), an environmental fungus, is an emerging opportunistic pathogen that causes focal or disseminated infection. Risk factors for cryptococcal infection include corticosteroid use, neoplasm, stem cell and solid organ transplantation, liver cirrhosis, chronic kidney disease, diabetes mellitus, rheumatologic disease, and infection with HIV.