Interferon gamma polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population
Shih-Wei Lee, Tzu-Yi Chuang, Hsiu-Han Huang, Kuei-Fang Lee, Tina Tu-Wen Chen, Yung-Hsi Kao, Lawrence Shih-Hsin Wu
Received: April 24, 2012 Revised: May 3, 2012 Accepted: November 21, 2012
Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
Corresponding author. Institute of Medical Sciences, Tzu Chi University, Number 701, Zhongyang Road, Sector 3, Hualien 97004, Taiwan.
Background and purpose:
Polymorphisms of the interferon gamma (IFN-γ) gene are associated with the risk of tuberculosis (TB) in different populations. However, the genetic susceptibility to TB in Han Chinese living in Taiwan is still unknown. The purpose of this study is to evaluate whether the polymorphisms of the IFN-γ gene are associated with TB in Han Taiwanese.
A total of 200 TB patients and 202 age-matched non-TB individuals were enrolled. Five tag single nucleotide polymorphisms (tSNPs) and rs2430561 (+874) of IFN-γ were selected from a public database. The genotypes were determined using polymerase chain reaction assays.
Three IFN-γ polymorphisms in intron 3, rs1861494 and rs2069718, and rs2430561 in interon 1 were strongly associated with TB. The C carrier (CT+TT) of rs1861494, TT homozygous of rs2069718, and AA homozygous of rs2430561 were risk genotypes for susceptibility to TB.
The IFN-γ polymorphisms, rs1861494, rs2069718, and rs2430561, may confer the risk of TB in Han Taiwanese.
IFN-γ, Polymorphism, Tuberculosis