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Volume 48, Number 3, June 2015

Elderly infection in the community due to ST5/SCCmecII methicillin-resistant Staphylococcus aureus (the New York/Japan clone) in Japan: Panton–Valentine leukocidin-negative necrotizing pneumonia 


Olga Khokhlova, Yusuke Tomita, Wei-Chun Hung, Tomomi Takano, Yasuhisa Iwao, Wataru Higuchi, Akihito Nishiyama, Ivan Reva, Tatsuo Yamamoto


Received: May 23, 2012    Revised: September 1, 2012    Accepted: September 17, 2012   

 

Corresponding author:

Tatsuo Yamamoto
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan
Correspondence
Corresponding author. Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University, Graduate School of Medical and Dental Sciences, 757 Ichibanchou, Asahimachidori, Niigata 951-8510, Japan. 



 

Background and purpose: 

An 89-year-old man suffered from and died of necrotizing pneumonia with rapid progression and cavity formation due to methicillin-resistant Staphylococcus aureus (MRSA). He was at no risk for hospital-acquired MRSA infection. His MRSA exhibited genotype ST5/spa2(t002)/agr2/SCCmecII/coagulaseII and was negative for Panton–Valentine leukocidin, indicating the New York/Japan clone (the predominant epidemic hospital-acquired MRSA clone in Japan). However, this strain expressed the cytolytic peptide (phenol-soluble modulin or δ-hemolysin) genes at high level, similar to USA300 (the most common community-acquired MRSA in the United States), indicating a variant of the New York/Japan clone with an important feature of community-acquired MRSA. 



 

Key words:

Community-acquired necrotizing pneumonia, Elderly infection, Methicillin-resistant Staphylococcus aureus (MRSA), New York/Japan clone