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Volume 48, Number 1, February 2015

Development of antiviral agents toward enterovirus 71 infection 

Hamid Reza Pourianfar, Lara Grollo

Received: October 30, 2013       Accepted: November 16, 2013   


Corresponding author:

* Corresponding author. Iranian Academic Centre for Education,
Culture and Research (ACECR)dMashhad Branch, P.O. Box 91775-
1163, Mashhad, Iran.
E-mail address: (H.R. Pourianfar). 


Background and purpose: 

Enterovirus 71 (EV71) infection remains a public health problem at a global level, particularly in the Asia-Pacific region. The infection normally manifests as hand–foot–mouth disease; however, it is capable of developing into potentially fatal neurological complications. There is currently no approved vaccine or antiviral substance available for the prevention or treatment of EV71 infection. This paper, thus, reviews efforts to develop or discover synthetic as well as naturally occurring compounds directed against EV71 infection. The recent achievements in cellular receptors of EV71 are also highlighted, and their contribution to the development of antiviral drugs against EV71 is discussed in this article. 


Key words:

Antiviral agents, EV71 infection, EV71 receptors, Phytochemicals