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Volume 47, Number 6, December 2015

A report on the first outbreak of a single clone group A Streptococcus (emm-type 89) tonsillopharyngitis in China 

Ying-Mei Liu, Jian-Zhong Zhao, Bin-Bin Li, Jun-Yong Yang, Xiao-Gen Dong, Jian-Jun Zhang, Bin Cao

Received: March 30, 2013    Revised: July 15, 2013    Accepted: August 8, 2013   


Corresponding author:

* Corresponding author. Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical
University, Number 8 Gongren Tiyuchang South Road, Chaoyang District, Beijing 100020, People’s Republic of China.
** Corresponding author. Center for Disease Control and Prevention, Number 3 Xi An Road, Fengtai District, Beijing 100071, People’s Republic
of China.
E-mail addresses: (J.-J. Zhang), (B. Cao). c These authors contributed equally to this work. 


Background and purpose: 

In 2012, 28 out of 140 staff working for a film crew in a Beijing movie and television base experienced a sudden onset of fever, sore throat, and/or tiredness, headache within the 24 hour period of July 26–27. All of the patients visited the hospital and were diagnosed as having tonsillopharyngitis. On July 28, 2012, a team of Centers for Disease Control and Prevention staff arrived and initiated an outbreak investigation. Pharyngeal swabs were obtained from patients for microbiologic analysis. All isolates of the outbreak were analyzed for toxin-genes and drug-resistance genes by polymerase chain reaction, and were performed for the emm typing and pulsed-field gel electrophoresis typing. On July 30, 2012, Group A Streptococcus was isolated from eight of the 16 throat swab specimens obtained on site. These isolates were found to have the same genotype emm 89. This is the first report to identify Group A Streptococcus emm type-89 as a cause of tonsillopharyngitis in Beijing, China. 


Key words:

emm-type 89, Film crew, Group A Streptococcus, Outbreak, Tonsillopharyngitis