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Volume 47, Number 5, October 2014

Clinical analysis of Enterobacter bacteremia in pediatric patients: A 10-year study 

Hui-Lan Chen, Jen-Her Lu, Hsin-Hui Wang, Shu-Jen Chen, Chun-Jen Chen, Keh-Gong Wu, Ren-Bin Tang

Received: July 17, 2012    Revised: February 7, 2013    Accepted: March 27, 2013   


Background and purpose: 

Enterobacter species has emerged as an important pathogen of nosocomial bacteremia. The purpose of this study is to review the clinical characteristics of bacteremia in pediatric patients. 



We reviewed retrospectively the medical records of patients (under the age of 18 years) having Enterobacter bacteremia who were treated at Taipei the Veterans General Hospital from January 2001 to June 2011. 



In total, 853 positive blood cultures were obtained from 620 patients during the study period. Among them, 96 episodes of Enterobacter bacteremia were found in 83 patients, accounting for 11.3% of all bacteremia. Eighty-two cases (98.8%) were nosocomial infections. Most of the cases were neonates (62 cases, 74.7%) and premature infants (51 cases, 61.5%). The common sources of bacteremia were the respiratory tract (53.0%), followed by intravascular catheter (10.8%), multiple sources (10.8%), and the gastrointestinal tract (8.4%). The overall case fatality rate was 18.1%, with the highest rate being reported among premature infants. The factors responsible for the deaths were leukocytosis and a higher median number of underlying diseases. 



Based on the findings of the present study, it can be concluded that Enterobacter species are probably an important pathogen of nosocomial bacteremia in premature neonates. The number of underlying diseases should be considered a major factor influencing the prognosis. 


Key words:

Bacteremia, Enterobacter, Neonates