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Volume 47, Number 3, June 2014

Kawasaki disease with G6PD deficiency—Report of one case and literature Review 


Chia-Hao Chen, Li-Yan Lin, Kuender D. Yang, Kai-Sheng Hsieh, Ho-Chang Kuo*


Received: October 25, 2011    Revised: March 1, 2012    Accepted: March 3, 2012   

 

Corresponding author:

Corresponding author. Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, No. 123 Ta-Pei Road, Niaosong, Kaohsiung 83301, Taiwan. 



 

Background and purpose: 

Kawasaki disease (KD) is a systemic vasculitis primarily affecting children who are younger than 5 years. The most serious complications are coronary artery aneurysms and sequelae of vasculitis with the subsequent development of coronary artery aneurysm. According to the literature, intravenous immunoglobulin (IVIG) plus high-dose aspirin (acetylsalicylic acid) were standard treatment for KD, whereas low-dose aspirin (3-5 mg/kg/day) was used for thrombocytosis in KD via antiplatelet effect. However, aspirin has been reported to have hemolytic potential in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a child with G6PD-deficiency who has KD, and review the literature. 



 

Key words:

Aspirin, G6PD deficiency, Kawasaki disease