Kawasaki disease with G6PD deficiency—Report of one case and literature Review
Chia-Hao Chen, Li-Yan Lin, Kuender D. Yang, Kai-Sheng Hsieh, Ho-Chang Kuo*
Received: October 25, 2011 Revised: March 1, 2012 Accepted: March 3, 2012
Corresponding author. Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, No. 123 Ta-Pei Road, Niaosong, Kaohsiung 83301, Taiwan.
Background and purpose:
Kawasaki disease (KD) is a systemic vasculitis primarily affecting children who are younger than 5 years. The most serious complications are coronary artery aneurysms and sequelae of vasculitis with the subsequent development of coronary artery aneurysm. According to the literature, intravenous immunoglobulin (IVIG) plus high-dose aspirin (acetylsalicylic acid) were standard treatment for KD, whereas low-dose aspirin (3-5 mg/kg/day) was used for thrombocytosis in KD via antiplatelet effect. However, aspirin has been reported to have hemolytic potential in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a child with G6PD-deficiency who has KD, and review the literature.
Aspirin, G6PD deficiency, Kawasaki disease