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Volume 47, Number 3, June 2014

Investigation of the effectiveness of Syzygium aromaticum, Lavandula angustifolia and Geranium robertianum essential oils in the treatment of acute external otitis: A comparative trial with ciprofloxacin 

Yunes Panahi*, Asghar Akhavan, Amirhossein Sahebkar, Seied Mohammad Hosseini, Mohsen Taghizadeh, Hossein Akbari, Mohammad Reza Sharif, Saber Imani

Received: November 11, 2011    Revised: August 3, 2012    Accepted: October 1, 2012   


Corresponding author:

Corresponding author. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Molla-Sadra Street, P.O. Box 19945-581, Tehran, Iran. 


Background and purpose: 

Antibiotics and anti-inflammatory agents are the mainstay of acute external otitis (AEO) treatment. The present study investigated the effectiveness of a combination herbal drop (Lamigex) composed of essential oils from Syzygium aromaticum, Lavandula angustifolia, and Geranium robertianum in the alleviation of AEO symptoms and compared its effects to those of ciprofloxacin 0.3% drop. 



Seventy patients were randomly assigned to receive ciprofloxacin 0.3% (n = 35) or Lamigex (n = 35) drop. Each group was administered with three drops every 12 hours for a week. Patients were examined for AEO symptoms and ear discharge cultures at baseline as well as at the end of trial. Pain severity was also recorded using a visual analogue scale at baseline, the 3rd day, and the 7th day of the trial. 



All assessed symptoms (tenderness, itching, erythema, edema and discharge) were equally improved in the ciprofloxacin and Lamigex groups by the end of trial (p > 0.05). There were remarkable reductions in the visual analogue scale score by the end of trial in both groups (p < 0.001). However, the rate of pain improvement was not found to be significantly different between the groups, either at the 3rd or 7th day of trial (p > 0.05). The numbers of positive cultures for all tested microorganisms were clearly reduced by the end of the trial in both groups but were not significantly different between the groups (p > 0.05) 



The herbal combination drop that was investigated in the present study exhibited good efficacy in reducing the burden of infection as well as AEO symptoms.


Key words:

Acute external otitis, Ciprofloxacin, Clinical trial, Geranium robertianum, Infection, Inflammation, Lavandula angustifolia, Pain, Syzygium aromaticum