CD209 promoter –336 A/G (rs4804803) polymorphism is associated with susceptibility to pulmonary tuberculosis in Zahedan, southeast Iran
Mohammad Naderi, Mohammad Hashemi, Mohsen Taheri, Hossein Pesarakli, Ebrahim Eskandari-Nasab, Gholamreza Bahari
Received: November 16, 2012 Revised: January 31, 2013 Accepted: February 6, 2013
Corresponding author. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran.
Background and purpose:
The present study aimed at evaluating the possible association between CD209 rs4804803 (–336 A/G) gene polymorphism and pulmonary tuberculosis (PTB) in a sample of Iranian population.
This case–control study was performed on 156 PTB patients and 154 healthy individuals. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphisms.
Our findings revealed that the CD209 rs4804803 increased the risk of PTB in codominant [odds ratio (OR) = 5.16, 95% confidence interval (CI) = 1.60–16.59, p = 0.006, GG vs. AA], dominant (OR = 1.69, 95% CI = 1.07–2.66, p = 0.024, AG + GG vs. AA), and recessive (OR = 4.20, 95% CI = 1.34–13.16, p = 0.014, GG vs. AA + AG) tested inheritance models. Furthermore, the rs4804803 G allele increased the risk of PTB (OR = 1.58, 95% CI = 1.12–2.23, p = 0.011) as compared to the A allele.
Our data suggest that CD209 rs4804803 polymorphism increased the risk of PTB in a sample of Iranian population.
CD209, Single-nucleotide polymorphism, Tuberculosis