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Volume 46, Number 5, October 2013

Clinical features of different genotypes/genogroups of human metapneumovirus in hospitalized children 


Hsin-Yi Wei, Kuo-Chien Tsao, Chung-Guei Huang, Yhu-Chering Huang, Tzou-Yien Lin


Received: April 9, 2012    Revised: June 29, 2012    Accepted: September 28, 2012   

 

Corresponding author:

Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children’s Hospital, No. 5, Fu-Shin Street, Kweishan 333, Taoyuan, Taiwan.
E-mail address: ychuang@adm.cgmh.org.tw (Y.-C. Huang).

The first two authors contributed equally to this work. 



 

Background and purpose: 

To explore the clinical features of different human metapneumovirus (hMPV) genotypes/genogroups in hospitalized children. 



 

Methods:

From January 2005 to April 2010, 3313 children's respiratory specimens sent for the detection of respiratory syncytial virus antigen were also tested for hMPV by real time-polymerase chain reaction. Demographics, clinical presentations, and laboratory findings of patients infected with different genotypes/genogroups of hMPV were compared. 



 

Results:

A total of 725 samples were positive for hMPV (positive rate, 23%). The F gene was sequenced for 279 isolates; of these, genotype A was identified in 51% (A1, 6.1%; A2, 45%) and genotype B in 49% (B1, 19%; B2, 30%). Medical records of 152 hospitalized children were reviewed. Co-infection with other pathogens was 25.7% (39/152). Excluding co-pathogens other than respiratory syncytial virus, a total of 124 children were analyzed. The most common symptoms included cough, fever, rhinorrhea, wheezing and respiratory distress with accessory muscle usage. The main diagnosis was bronchiolitis. The most common chest radiographic findings were increased perihilar infiltrates. No significant difference was found in terms of demographics, clinical manifestations, and laboratory findings among the children infected with different serogroups of hMPV. 



 

Conclusion:

hMPV accounted for a substantial proportion of hospitalized children with lower respiratory tract infection with a high co-infection rate. The A2 subgroup was the most frequently observed, followed by B2. No significant difference was found among patients infected with different genotypes/genogroups of hMPV in terms of clinical manifestations. 



 

Key words:

Children, Genogroups, Genotype, Human metapneumovirus