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Volume 46, Number 4, August 2013

Human papillomavirus infection in human immunodeficiency virus-positive Taiwanese women incarcerated for illicit drug usage 


Fang-Yeh Chu, Yu-Shiang Lin, Shu-Hsing Cheng


Received: September 18, 2011    Revised: May 9, 2012    Accepted: June 11, 2012   

 

Corresponding author:

Corresponding author. Department of Infectious Diseases, Taoyuan General Hospital, Department of Health, 1492 Chung-Shan Road,
Taoyuan 330, Taiwan. E-mail address: shuhsingcheng@gmail.com (S.-H. Cheng). 



 

Background and purpose: 

The number of female injection drug users infected with human immunodeficiency virus (HIV) is increasing in Taiwan. Their human papillomavirus (HPV) infection has not been fully discussed. 



 

Methods:

A cross-sectional study was conducted in a prison for women. Both HIV-positive and HIV-negative women were enrolled voluntarily. All patients answered self﹣administered questionnaires, had a Pap smear, and underwent linear array HPV genotype tests.A cross-sectional study was conducted in a prison for women. Both HIV-positive and HIV-negative women were enrolled voluntarily. All patients answered selfadministered questionnaires, had a Pap smear, and underwent linear array HPV genotype tests. 



 

Results:

A total of 72 female patients infected with HIV and 76 women who were not infected with HIV were enrolled in this cross-sectional study (mean age, 33.4 years). HPV infection was detected in 63.9% of patients infected with HIV and 47.4% of HIV-negative counterparts (pZ0.043). Oncogenic HPV was detected in 41.6% of patients infected with HIV and 28.9% of their counterparts (pZ0.10). A mean of 2.41 types of HPV were detected in HIV-positive women and 1.53 types were detected in the HIV-negative counterparts (pZ0.014). HPV 52 was the most commonly encountered oncogenic type. Only 10.2% of the patients (10.9% of HIV-positive patients) had vaccine-preventable HPV types. Patients with abnormal cytology (81.3%) tended to have oncogenic types of HPV infection. HIV serostatus
was the significant factor associated with oncogenic HPV infection (odds ratioZ2.583, 95% confidence interval 1.071e6.231, pZ0.0347). 



 

Key words:

Drug abuse; Human immunodeficiency virus; Human papillomavirus; Women