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Volume 46, Number 2, April 2013

The clinical implications of ABO blood groups in Pseudomonas aeruginosa sepsis in children 


Kuang-Che Kuo, Ho-Chang Kuo, Li-Tung Huang, Chien-Seng Lin, San-Nan Yang


Received: October 5, 2011    Revised: October 27, 2011    Accepted: January 2, 2012   

 

Corresponding author:

Corresponding author.San-Nan Yang. Department of Pediatrics, Kaohsiung Medical University Hospital, Graduate Institute of Medicine, Kaohsiung
Medical University, Number 100, Tzyou 1st Road, Sanmin District, Kaohsiung City 807, Taiwan.
E-mail address: y520729@gmail.com (S.-N. Yang). 



 

Background and purpose: 

Pseudomonas aeruginosa (P. aeruginosa) sepsis is a fetal disease with rapid progressive shock for infants and children in hospital and in the community, without initial treatment with appropriate antibiotics. Because underlying risk factors remain unclear for affected patients, it is still difficult for early diagnosis and therapy. Recently, ABO blood group antigens were associated with several infectious diseases. However, it was not reported whether the ABO blood group could be the clinical implications for pediatric Pseudomonas sepsis. 



 

Methods:

This study retrospectively reviewed the medical records of 23 infants and children with P. aeruginosa sepsis, who were hospitalized at Kaohsiung Chang Gung Memorial Hospital from 2003 to 2009. 



 

Results:

Eight cases had nosocomial infections, with a higher mortality rate (50%) than 15 cases (26.7%) in the community. Thirteen patients (86.7%) with community-acquired sepsis were infants, significantly younger than the nosocomial cases. ABO blood group antigens were known in 21 cases and B phenotype was the most significant. In the community-acquired group, fever and diarrhea were the most prevalent symptoms on initial presentation. Moreover, pneumonitis was the most concomitant disease in fatal cases. 



 

Conclusion:

Blood group B was highly associated with pediatric P. aeruginosa sepsis. This could be a risk factor, and play an important role for the pathogenesis of P. aeruginosa sepsis. Furthermore, if a previously healthy infant with fever and diarrhea suddenly had septic presentation, P. aeruginosa infection should be considered. In addition, more intensive care could be needed for such blood group B pediatric patients, if pneumonitis was concomitant on admission for the high mortality rate. 



 

Key words:

ABO blood group antigens, Complication, Infants, Pseudomonas aeruginosa sepsis