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Volume 45, Number 6, December 2012

Complexity of β-lactamases among clinical Aeromonas isolates and its clinical implications


Po-Lin Chen, Wen-Chien Ko, Chi-Jung Wu


Received: August 1, 2012    Revised: August 8, 2012    Accepted: October 1, 2012   

 

Corresponding author:
  • Graduate Institute of Clinical Medicine, National Cheng Kung University, College of Medicine, Tainan, Taiwan
  • Department of Internal Medicine, National Cheng Kung University, College of Medicine and Hospital, Tainan, Taiwan
  • National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan
  • Corresponding Author InformationCorresponding author. National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Number 367, Sheng Li Road, 704 Tainan, Taiwan, ROC.


 

Background and purpose: 

Aeromonas species, aquatic Gram-negative bacilli, distributed globally and ubiquitously in the natural environment, may be implicated in a variety of human diseases. They can produce various β-lactamases which confer resistance to a broad spectrum of β-lactams, and therefore in vitro susceptibility testing must be used to guide antimicrobial therapy. However, conventional in vitro susceptibility tests may sometimes fail to detect these β-lactamases, and hence raise a therapeutic challenge. In this review article, two chromosomally mediated β-lactamases (i.e., AmpC β-lactamases and metallo-β-lactamases) and acquired extended-spectrum β-lactamases in aeromonads are reviewed, and the clinical implications of the complexity of β-lactamases are discussed.



 

Key words:

 AeromonasAmpCAntimicrobial therapyβ-lactamasesExtended-spectrum β-lactamaseMetallo-β-lactamase