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Volume 45, Number 2, April 2012

Patterns of sensitization to peanut allergen components in Taiwanese Preschool children


Yang-Te Lin, Chih-Te Charles W, Ju-Hui Cheng, Jing-Long Huang, Kuo-Wei Yeh


Received: July 8, 2011    Revised: July 13, 2011    Accepted: September 13, 2011   

 

Corresponding author:

Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, 5,
Fu-Hsin Street, Taoyuan, Taiwan.
E-mail address: kwyeh@adm.cgmh.org.tw (K.-W. Yeh).



 

Background and purpose: 

Peanut allergy is very common in Western countries, although it is
seldom encountered in Eastern countries. Peanuts are comprised of at least 11 components,
but the contribution to clinical symptoms by each component in each individual is not known.
This study investigated the distributions of sensitivity to peanut allergen components among
Taiwanese children who were sensitized to peanuts and followed the evolution of sensitization
patterns to these components.



 

Methods:

We enrolled 29 preschool children (ageZ2.11   1.36 years) who were sensitized to


peanuts above class 3. Serum was analyzed for specific immunoglobulin E (IgE) antibodies to


recombinant Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9. Allergen component-specific IgE


 0.35 kUA/L was defined as positive. Eighteen children were retested 22.64   5.1 months


later. Peanut allergy symptoms were recorded from detailed questionnaires.



 

Results:

The percentages of children sensitized to Ara h 1, 2, 3, 8, and 9 were, respectively,


51.8%, 65.5%, 62.1%, 13.8%, and 24.1%. Regarding changing patterns of peanut component


sensitization at follow-up, children with clinical symptoms to peanuts had persistent elevations


of Ara h 2-specific IgE: 12.6   1.01 up to 34.15   19.4 kUA/L; pZ0.144. In contrast,


Ara h 2 concentrations decreased significantly in children without clinical symptoms. Ara h 8


and 9 were nonspecific for children with or without symptoms.



 

Conclusion:

Ara h 1, Ara h 2, and Ara h 3 were major components contributing to peanut sensitization
in Taiwanese children. Ara h 2 was probably the most important component that
contributed to clinical symptoms and remained steady in children who had peanut allergy



 

Key words:

allergy; Arachis hypogaea; Asian;children; component-resolved diagnosis; peanut