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Volume 44, Number 6, December 2011

Regulation of immune responses, apoptosis, and tumorigenesis by separate FOXP-3-dependent genes: Connection with clinical manifestations

Oxana V. Klimenko

Received: October 1, 2009    Revised: May 4, 2010    Accepted: July 24, 2010   


Corresponding author:

Oxana V. Klimenko, Department of Pediatrics and Center forApplied Genomics, 1st School of Medicine, Charles University, KeKarlovu 2, Prague 2, 120 00, Czech Republic.


Background and purpose: 

 Recently, forkhead/winged-helix family box protein P3 (FOXP-3) was described as the main regulator of regulatory T cells’ activity. This transcription factor has the ability to control the immunosuppressive response of regulatory T cells. FOXP-3 has binding sites for different genes specific for proteins with various important functions. In this article, selected FOXP-3-dependent genes with known functions were divided into two groups. The first group of genes has main immunoregulatory functions, and the second group has the ability to regulate apoptosis and tumorigenesis. Investigation of the functions of all FOXP-3-dependent genes opens perspectives for applications in different fields of basic and clinical research.