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Volume 44, Number 5, October 2011

Diagnostic utility of enzyme-linked immunospot assay for interferon-γ in a patient with tuberculous arthritis and pyomyositis


Che-Kim Tan, Chih-Cheng Lai, Sheng-Hsiang Lin, Yu-Tsung Huang, Chun-Hsing Liao, Po-Ren Hsueh


Received: February 19, 2010    Revised: March 2, 2010    Accepted: March 8, 2010   

 

Corresponding author:

 Po-Ren Hsueh, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan



 

Background and purpose: 

The indolent and nonspecific presentations of tuberculous arthritis and pyomyositis render their diagnosis a great challenge for clinicians. We describe a 78-year-old man with swelling and pain of right knee for 6 months. The patient was empirically treated for tuberculosis because positive enzyme-linked immunospot assay for interferon-γ of blood was reported at 2 days after aspiration of synovial fluid, which was negative for acid-fast stain but subsequently grew Mycobacterium tuberculosis 6 weeks later. He recovered uneventfully with 1-year antituberculous combination therapy.



 

Key words:

Enzyme-linked immunospot assay, Interferon-γ, Mycobacterium tuberculosis, Tuberculous arthritis, Tuberculous pyomyositis