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Volume 44, Number 4, August 2011

Risk factors associated with Sphingomonas paucimobilis infection


Han-Siong Toh, Hung-Tze Tay, Wei-Khie Kuar, Tzu-Chieh Weng


Received: April 1, 2010    Revised: July 20, 2010    Accepted: August 5, 2010   

 

Corresponding author:

Department of Intensive Care, Chi-Mei Medical Center, 901, Chunghua Road, Yungkang City, Tainan County,Taiwan. E-mail address: chekim.tan@gmail.com (C.-K. Tan)



 

Background and purpose: 

Sphingomonas paucimobilis is rarely isolated from clinical specimens and it is associated with a great variety of infections. The aim of this study is to investigate the microbiological and clinical features of S paucimobilis infection in southern Taiwan



 

Methods:

S paucimobilis isolates from the microbiology laboratory of Chi-Mei Medical Center and their relevant clinical data from October 2005 to October 2009 were retrospectively reviewed.



 

Results:

A total of 55 patients with documented S paucimobilis infections were identified. Among them, 29 (52.7%) have community-acquired infections and 13 of them presented with primary bacteremia (44.8%). Multivariate logistic regression showed that community-acquired infection [adjusted odds ratio 13.473, 95% confidence interval (CI) 1.79–101.41, p=0.01], diabetes mellitus (adjusted odds ratio 7.03, 95% CI 1.16–42.66, p=0.03), and alcoholism (adjusted OR 10.87, 95% CI 1.00–117.69, p=0.05) were significant risk factors for S paucimobilis primary bacteremia. Most of those who have health care-associated S paucimobilis infections presented with pneumonia (10 of 26, 38.5%) and only 7.7% presented with catheter-related infection. The overall mortality rate was 5.5%.



 

Conclusion:

Community-acquired S paucimobilis infections were not uncommon, mainly presenting with primary bacteremia. Multivariate analysis showed that community-acquired infection, diabetes mellitus, and alcoholism were significant risk factors for primary bacteremia.



 

Key words:

Bacteremia, Community-acquired infection, Sphingomonas paucimobilis