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Volume 44, Number 3, June 2011

Impact of delayed diagnosis in children with primary antibody deficiencies

Asghar Aghamohammadi, Ahmad Bahrami, Setareh Mamishi, Babak Mohammadi, Hassan Abolhassani, Nima Parvaneh, Nima Rezaei

Received: April 20, 2010    Revised: June 10, 2010    Accepted: August 4, 2010   


Corresponding author:

Children’s Medical Center Hospital, Dr Qarib St, Keshavarz Blvd, Tehran 14194, Iran.
E-mail address: (S. Mamishi).


Background and purpose: 

Primary antibody deficiencies (PADs) are heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent infections. To evaluate the diagnostic delay in Iranian PADs in association with their infections, we scored such manifestations to find an association between such delay and the scoring system.



Forty-eight patients with PADs, who were referred to our center during a 25-year period, were enrolled in this study. Each episode of infection, before making the PADs diagnosis, got a score of 5 or 10 based on the severity of infections.



The diagnosis was made with median delay of 34.5 months, when the patients had mean score of 94.48 ± 52.89. There was a significant direct association between this scoring system and delay diagnosis. The score of 50 was considered as the cutoff point in our patient group. In this score, the suspicions to PADs in more than 90% of patients true positively lead to diagnosis of PADs.



Although diagnosis delay significantly decreased over time, PADs still continue to be diagnosed late. Based on the results of this study, the assessment of immune system should be performed in the patients with 50 total score or about 25 score per year.


Key words:

Delay, Diagnosis, Infection, Predominantly antibody deficiencies