Predictors of mortality in surgical patients with Acinetobacter baumannii bacteremia
Su-Jung Chen, Tze-Fan Chao, Mei-Chun Chiang, Shu-Chen Kuo, Liang-Yu Chen, Dung-Hung Chiang, Ti Yin, Te-Li Chen, Chang-Phone Fung
Received: March 12, 2010 Revised: May 4, 2010 Accepted: July 27, 2010
Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2,
Shih-Pai Rd, Taipei 11217, Taiwan.
E-mail address: firstname.lastname@example.org (T.-L. Chen).
Background and purpose:
Acinetobacter baumannii has emerged as an important pathogen of nosocomial infection. The aim of this study was to evaluate the predictors of poor outcome in surgical patients with A baumannii bacteremia.
We retrospectively recruited a total of 50 patients who developed A baumannii bacteremia within 2 weeks after surgery during a 113-month period. The primary outcome for this study was all-cause 14-day mortality. Clinical and laboratory data, antimicrobial susceptibility, treatment, and Sequential Organ Failure Assessment (SOFA) score were evaluated as possible predictors of outcome.
The 14-day mortality was 20% and there was no association between type of surgery and mortality. The SOFA score was the only independent predictor of 14-day mortality after adjustment for other variables. The calibration was acceptable (Hosmer-Lemeshow χ2 = 3.65, p = 0.72) and the discrimination was good (area under the receiver operating characteristic curve: 0.80 ± 0.07, 95% confidence interval, 0.67–0.94). We found that a SOFA score ≥7 was a significant predictor of 14-day mortality in surgical patients with A baumannii bacteremia.
The SOFA score assessed at the onset of bacteremia is a reliable tool for predicting 14-day mortality in surgical patients with A baumannii bacteremia.
Acinetobacter baumannii, Bacteremia, Mortality, SOFA score, Surgical