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Volume 43, Number 6, December 2010

Seroprevalence of Hepatitis D Virus and its Risk Factors in the West of Iran

Amir Houshang Mohammad Alizadeh, Mitra Ranjbar, Ali Shabahang Saber Tehrani, Fariba Keramat, Moggan Mamani, Mehdi Rezazadeh, Peyman Aini, Alireza Khalilian, Amir Majlesi, Mehrdad Hajilooi

Received: August 18, 2008    Revised: December 15, 2008    Accepted: January 7, 2009   


Corresponding author:

Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 7 floor, Taleghani Hospital Parvaneh Ave, Tabnak Str, Evin, Tehran 19857, Iran. P.O. Box: 19835-178


Background and purpose: 

Despite the decreasing trend in hepatitis D virus (HDV) infection worldwide, the importance of this
disease cannot be underestimated. The aim of this study was to evaluate patients positive for HBsAg with
respect to HDV infection and related factors. Patients with chronic hepatitis B who presented at Hamedan
Province Hepatitis Community Center in 2002–2007 were included. A questionnaire covering demo-
graphic variables and history of hepatic disease was completed for each patient. Necessary tests were
performed and antibodies to HDV were measured using an enzyme-linked immunosorbent assay. Of 81
HBsAg positive patients, 14 (17.3%) contained anti-HDV IgG. Only one of the patients with anti-HDV
IgM was positive for HBsAg. Of the anti-HDV IgG positive patients, two (14.3%) were women. Among the
women examined in this study, 24 (35.8%) were anti-HDV IgG negative (p = 0.21), and of these, six (42.8%)
were HBeAg positive while 17 (25.4%) of the anti-HDV IgG negative women were positive for HBeAg
(p = 0.16). The prevalence of chronic hepatitis B among anti-HDV IgG positive and negative patients was
28.6% and 39.2% respectively (p = 0.31). Because of the relatively high rate of hepatitis B virus (HBV) and
HDV co-infection in our study subjects, it is vital that healthcare providers and policy makers to recognize
the risk factors associated with this HBV and HDV co-infection as well as the reasons for this increased
anti-HDV serology in HBV carriers.


Key words:

HBeAg, hepatitis B virus, hepatitis D virus, Iran