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Volume 43, Number 6, December 2010

Staphylococcus lugdunensis Infective Endocarditis: A Literature Review and Analysis of Risk Factors

Po-Yen Liu, Yung-Feng Huang, Chia-Wan Tang, Ying-Yao Chen, Kai-Sheng Hsieh, Luo-Ping Ger, Yao-Shen Chen, Yung-Ching Liu

Received: April 30, 2009    Revised: June 20, 2009    Accepted: August 25, 2009   


Corresponding author:

Yung-Feng Huang, 386 Dazhong 1st Road, Zuoying District, Kaohsiung 813, Taiwan. E-mail:


Background and purpose: 

Infective endocarditis caused by Staphylococcus lugdunensis is a rare disease. Since its first description in 1988, there have only been a few reports of this disease and the causative organism. These publications were primarily case reports and brief case series. We conducted a literature review to identify the nature of the disease and its risk factors.



We retrospectively reviewed the cases reported between 1988 and 2008 by searching the relevant literature using the keywords “endocarditis” and “Staphylococcus lugdunensis” in the Medline database. All cases included met the definition of the modified Duke criteria.



For the period 1988–2008, 67 cases from 27 articles were reviewed. The mean age of individuals was 53.9 years. Left-sided valvular endocarditis represented 52 (82.5%) of cases and native-valve endocarditis was evident in 48 (78.7%) of cases. A large proportion (82%) of 50 S. lugdunensis strains were susceptible to
penicillin. Valve replacement operations were performed in 42 (66.7%) patients and the mortality rate was
38.8%. Univariate analysis showed a higher mortality rate in patients aged more than 50 years, those treated before 1995, those treated with antibiotics alone, and those with growth not detected by echocar-
diography. Medical treatment alone was the independent risk factor for mortality by multivariate analysis.



S. lugdunensis endocarditis led to substantial morbidity and mortality. Detailed microbiological identification, echocardiography evaluation, and valve replacement may improve the clinical outcome of individuals with S. lugdunensis endocarditis.


Key words:

infective endocarditis, risk factors, Staphylococcus lugdunensis