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Volume 43, Number 4, August 2010

Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation   

Marie-Olivia Chandesris, Charikleia Kelaidi, Frédéric Méchaï, Marie-Elisabeth Bougnoux, Nicole Brousse, Jean-Paul Viard, Sylvain Poirée, Marc Lecuit, Olivier Hermine, Olivier Lortholary

Received: April 30, 2009    Revised: June 10, 2009    Accepted: July 15, 2009   


Corresponding author:

Marie-Olivia Chandesris, Service d'hématologie, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France


Background and purpose: 

Chronic disseminated candidiasis is a complication of the intensive therapies of hematological malignancies revealed during hematopoietic recovery, a context reminiscent of the immune restoration inflammatory syndrome in human immunodeficiency virus patients receiving antiretroviral therapy. We report a case of severe exacerbation of chronic disseminated candidiasis after pegylated granulocyte-colony stimulating factor administration. We emphasize the major inflammatory substrate of the disease and suggest that immune-modulating strategies such as hematopoietic growth factors, should be used cautiously in such patients.


Key words:

chronic disseminated candidiasis  ,  hematopoietic growth factors  ,  hepatosplenic candidiasis  ,  immune restoration inflammatory syndrome