Risk Factors for Bloodstream Infections due to Extended-spectrum β-lactamase-producing Escherichia coli
Un-In Wu, Ching-Shiang Yang, Wan-Chin Chen, Yee-Chun Chen, Shan-Chwen Chang
Received: April 20, 2009 Revised: July 5, 2009 Accepted: August 3, 2009
Shan-Chwen Chang, Division of Infectious Diseases, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan
Background and purpose:
The risk factors for production of extended-spectrum β-lactamases (ESBLs) have rarely been studied for bloodstream infections of Escherichia coli alone. A case-control study was undertaken to identify the risk factors associated with bloodstream infections caused by ESBL producing E. coli
From January 1, 2005 to June 30, 2007, all patients with a confirmed diagnosis of bloodstream infection caused by ESBL-producing E. coli were reviewed. Each patient was matched with one control subject who experienced ESBL-negative E. coli bacteremia during the same study period.
More judicious use of antimicrobial agents, especially oxyimino-cephalosporins, and avoidance of urinary catheterization may decrease the possibility of ESBL-producing E. coli bacteremia in hospitalized patients.
bacteremia , bloodstream infection , case-control study , Escherichia coli , extended-spectrum β-lactamase , risk factor