An Outbreak of Coxsackievirus A16 Infection: Comparison With Other Enteroviruses in a Preschool in Taipei
Pei-Chieh Wu, Li-Min Huang, Chuan-Liang Kao, Tsui-Yen Fan, Ai-Ling Cheng, Luan-Yin Chang
Received: December 15, 2008 Revised: April 2, 2009 Accepted: August 14, 2009
Luan-Yin Chang, Division of Pediatric Infectious Disease, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung-Shan South Road, Taipei 10002, Taiwan
Background and purpose:
The transmission rate of enteroviruses in young children remains unclear. Therefore, we carried out active surveillance in preschool children to investigate the transmission rate and clinical manifestation of enteroviruses.
From September 2006 to December 2008, we monitored infectious diseases in children 2(–3 years of age) in a preschool in Taipei. If any child had a febrile illness or symptoms/signs of enteroviral infection [e.g. herpangina or hand-foot-and-mouth disease (HFMD)], we performed viral isolation and enterovirus polymerase chain reaction. VP1 sequencing was performed to define their serotypes. We also collected clinical data and analyzed transmission rates.
Compared with CA2 and CA4, CA16 infections resulted in more cases of HFMD and had significantly higher transmission rates in preschoolers.
coxsackievirus A16 , enterovirus , transmission rate