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Volume 42, Number 5, October 2009

 Activity of ertapenem, ciprofloxacin, ceftriaxone, piperacillintazobactam, and ampicillin-sulbactam against 12 common clinical isolates of community-acquired bacteremia


Kao-Pin Hwang, Ya-Fen Tang, Yea-Huei Shen


Received: September 2, 2008    Revised: April 16, 2008    Accepted: June 16, 2008   

 

Corresponding author:

Dr. Yea-Huei Shen, Infection Control Committee, Yuan General Hospital, 162 Cheng-Kung 1st Rd., Kaohsiung, Taiwan.

E-mail: shen7291@yahoo.com.tw

 

 



 

Background and purpose: 

 

 To compare the antimicrobial activities of ertapenem, ciprofloxacin, ceftriaxone, piperacillin-tazobactam, and ampicillin-sulbactam against 12 common organisms that cause communityacquired bacteremia and to identify the most active agents for the treatment of extended-spectrum β-lactamase (ESBL)–producingEscherichia coli and Klebsiella pneumoniae

 



 

Methods:

1200 blood specimens from patients with community-acquired bacteremia were collected at Chang Gung Memorial Hospital, Kaohsiung, Taiwan. All isolates were identified by the API system, and each culture’s antimicrobial susceptibility was determined by the standard disk-diffusion method. The minimal inhibitory concentrations of the antibiotics were detected by the Epsilimeter test.

 

 



 

Results:

   The in vitro susceptibilities of 11 of the 12 common pathogens to ertapenem were 100%. The frequency of ESBL-producing E. coli and K. pneumoniae was 6.2% and 9.5%, respectively. Only 48% and 50% of E. coliand K. pneumoniae, respectively, were susceptible to ciprofloxacin. These data infer that ciprofloxacin should not be given for ESBL-producing E. coli and K. pneumoniae. Ceftriaxone and piperacillin-tazobactam had high activity against the most common pathogens isolated



 

Conclusion:

 ESBL E. coli and K. pneumoniae are highly resistant to ciprofloxacin, so this antibiotic should be avoided for patients with community-acquired bacteremia. ESBL E. coli and K. pneumoniae are highly susceptible to ertapenem