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Volume 36, Number 3, September 2003

Fluconazole resistance rate of Candida species from different regions and hospital types in Taiwan


Yun-Liang Yang, Hsiao-Hsu Cheng, Yong-An Ho, Chin-Fu Hsiao, Hsiu-Jung Lo
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC

 

Methods:

From April 15 to June 15, 1999, 581 clinical Candida isolates from 19 hospitals in Taiwan were collected and susceptibilities to fluconazole of these isolates were determined by a broth microdilution method. A total of 42 (7.2%) isolates were resistant to fluconazole. Isolates from medical centers had a higher resistance rate to fluconazole than those from regional hospitals (10.7% vs 4.9%). Candida species isolated from different regions had different degrees of susceptibility to fluconazole. Approximately 2.5%, 6.5%, and 11.8% of Candida isolates from middle, north, and south regions, respectively, were resistant to fluconazole. The prevalence of the combination of Candida glabrata, Candida krusei, and Candida tropicalis infections were 44.5%, 49.8%, and 62.7% in middle, north, and south regions, respectively. There is an association between the rate of fluconazole resistance and the number of non-albicans Candida species collected from different regions and hospital types.

 



 

J Microbiol Immunol Infect 2003;36:187-191.