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Volume 37, Number 3, June 2004

Chronic mucocutaneous candidiasis in a 6-year-old boy


Shih-Jung Chiu, Ching-Hsiung Tsao, Li-Chen Chen, Chun-Chieh Kao, Ko-Huang Lue, Jing-Long Huang
Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children¡¦s Hospital and Chang Gung University, Taoyuan; Department of Pediatrics, Li Shin Hospital, Taoyuan; Department of Pediatrics, St. Paul¡¦s Hospital, Taoyuan; Department of Pediatrics, Chung Shan Medical College Hospital, Taichung, Taiwan, ROC

Received: May 5, 2003    Revised: September 2, 2003    Accepted: September 24, 2003   

 

Corresponding author:

Dr. Jing-Long Huang, Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children¡¦s Hospital, 5, Fu-Hsin Street, Kueishan, Taoyuan, Taiwan 333, ROC. E-mail: long@adm.cgmh.org.tw This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 



 

Methods:

Chronic mucocutaneous candidiasis (CMC) is a complex disorder characterized by persistent or recurrent candidal infections of the skin, nails and/or mucous membranes. A familial occurrence has been reported in some instances, suggesting a genetic predisposition. CMC has also been suggested to be associated with a selective defect in T cell-mediated immunity to Candida antigens. Reports of cases in Asians are rare. We report a case of CMC in a 6-year-old boy with chronic candidal infection since 7 months of age. The patient presented with deficient cell-mediated immunity and decreased natural killer cells. This case highlights the need for detailed studies for evaluating the T-cell immunity in patients with chronic candial infection.

 



 

Key words:

Case reports, cellular immunity, chronic mucocutaneous candidiasis, diagnosis



 



 

J Microbiol Immunol Infect 2004;37:196-199.