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Volume 38, Number 1, February 2005

Clinical manifestations of Kikuchi\\\'s disease in southern Taiwan

Hsin-Liang Yu, Susan Shin-Jung Lee, Hung-Chin Tsai, Chun-Kai Huang, Yao-Shen Chen, Hsi-Hsin Lin, Shue-Ren Wann, Yung-Ching Liu, Hui-Hwa Tseng
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung; and Department of Pathology, National Yang-Ming University, Taipei, Taiwan *Current affiliation: Department of Internal Medicine, Kaohsiung Municipal Min Seng Hospital, Kaohsiung, Taiwan

Received: March 22, 2004    Revised: June 21, 2004    Accepted: June 30, 2004   


Corresponding author:

Dr. Yung-Ching Liu, Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, No. 386, Ta-Chung First Road, Kaohsiung 813, Taiwan. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it




Histiocytic necrotizing lymphadenitis, or Kikuchi's disease (KD), is a self-limiting cervical lymphadenitis of unknown origin. The diagnosis of KD is problematic due to the lack of specific laboratory tests. This study reviewed the clinical characteristics of 58 patients with KD. Clinical manifestations were of considerable diversity. The mean age of patients was 24.88 ± 7.44 years and there was a female predominance (1.76:1). The most frequent clinical findings were enlarged tender lymph nodes (50%), fever (43%), sore throat (21%), non-productive cough (12%), headache (10%), chills (9%) and rhinorrhea (9%). The most common initial laboratory abnormalities were leucopenia (29%), elevated erythrocyte sedimentation rate (14%), liver function impairment (14%), elevated C-reactive protein level (12%), and anemia (10%). Most patients had unilateral lymph node involvement (79%), which was usually located in the posterior triangle of the cervical lymph nodes (90%). Most patients had no comorbid disease (93%). No recurrence occurred. KD should be included in the differential diagnosis of fever with cervical lymphadenopathy.



Key words:

Apoptosis, differential diagnosis, histiocytic necrotizing lymphadenitis, Kikuchi's disease, signs and symptoms



J Microbiol Immunol Infect 2005;38:35-40.