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Volume 38, Number 2, April 2005

Methylprednisolone pulse therapy for massive lymphadenopathy in a child with intravenous immunoglobulin-resistant Kawasaki disease

Hsin-Hsu Chen, Po-Mai Liu, Chin-Nam Bong, Yu-Tsun Wu, Kuender D. Yang, Chih-Lu Wang
Department of Pediatric Allergy, Immunology and Rheumatology, Chang Gung Children's Hospital, Kaohsiung; Department of Pediatrics, Pingtung Christian Hospital, Pingtung; and Department of Pediatrics, Yunlin Huwei St. Joseph Hospital, Yunlin Hsien, Taiwan

Received: April 16, 2004    Revised: June 24, 2004    Accepted: July 1, 2004   


Corresponding author:

Chih-Lu Wang, MD, PhD, Department of Pediatric Allergy, Immunology and Rheumatology, Chang Gung Children¡·s Hospital, 123, Ta-Pei Road, Niaosung Hsiang, Kaohsiung 833, Taiwan. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it




Kawasaki disease (KD) is an acute febrile multi-system vasculitis of unknown etiology. The diagnosis is based on clinical features. We describe a case of intravenous immunoglobulins (IVIG)-resistant KD presenting with persistent fever and massive cervical lymphadenopathy associated with mild respiratory distress. The symptoms resolved after methylprednisolone pulse therapy. High-dose pulse steroid may be an alternative therapeutic option in KD which presents with possible life-threatening complications or failure to respond to high-dose IVIG infusion.



Key words:

Drug pulse therapy, intravenous immunoglobulins, methylprednisolone, mucocutaneous lymph node syndrome



J Microbiol Immunol Infect2005;38:149-152.