Thymoma and hypogammaglobulinemia (Good\\\'s syndrome): a case report
Yi-Giien Tsai, Jenn-Haung Lai, San-Yuan Kuo, Hsiang-Cheng Chen, Deh-Ming Chang
Department of Pediatrics, Christian Hospital, Institute of Medical Research, Chang Jung Christian University, Changhua; and Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Received: November 7, 2003 Revised: November 30, 2003 Accepted: August 9, 2004
Good's syndrome is extremely rare and refers to an acquired B and T cell immunodeficiency in thymoma patients. We report a 51-year-old female thymoma patient who presented with recurrent herpes zoster, pneumonia, diarrhea and opportunistic infections. She was found to have acquired hypogammaglobulinemia with absent B cells. Despite repeat intravenous immunoglobulin replacement and antibiotic therapy, she died of bacterial pneumonia-induced acute respiratory distress syndrome. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with recurrent infections.
J Microbiol Immunol Infect 2005;38:218-220.