Seroprevalence of melioidosis in diabetic patients in Taiwan
Wen-Tsair Chen, Yao-Shen Chen, Soi-Moi Chye, Tsu-Rong Wu, Wen-Gui Hong, Yun-Nan Lin, Hong-Twn Bair, Shu-Chi Yang, Ya-Lei Chen
Department of Laboratory Medicine, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung; Infectious Disease Section, Kaohsiung Veterans General Hospital, Kaohsiung; Graduate Institute of Environmental Education, National Kaohsiung Normal University, Kaohsiung; Department of Medical Technology, Fooyin University, Kaohsiung; and Department of Pathology, The Cancer Society of Kaohsiung City, Kaohsiung, Taiwan
Received: September 20, 2004 Revised: January 31, 2005 Accepted: February 14, 2005
Diabetes mellitus is a major predisposing factor for Burkholderia pseudomallei infection. This study surveyed serum samples from 356 Taiwanese patients with diabetes mellitus for anti-flagellin antibodies against B. pseudomallei. Antibody titer to B. pseudomallei was positive in 3.0% (11/365) of diabetes mellitus patients. All seropositive individuals were aged >60, indicating that elderly and diabetic adults are at high risk of B. pseudomallei infection. In this study, diabetic females, who were usually housewives, had a seropositive rate of 81.1%. However, the incidence of melioidosis in males (usually working outdoors) was 93.7% based on clinical cases. We suggest that exposure of males and females to B. pseudomallei in this study was via different routes of infection.
Bacterial antibodies, Burkholderia pseudomallei, melioidosis, seroepidemiologic studies
J Microbiol Immunol Infect 2005;38:267-270.