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Volume 38, Number 5, October 2005

Common variable immunodeficiency mimicking rheumatoid arthritis with Sjögren\\\'s syndrome


Li-Hsin Lin, Chih-Neng Tsai, Ming-Fei Liu, Chrong-Reen Wang
Section of Rheumatology and Section of Allergy and Immunology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

Received: August 20, 2004    Revised: December 25, 2004    Accepted: March 25, 2005   

 

Corresponding author:

Dr. Li-Hsin Lin, Section of Rheumatology and Section of Allergy and Immunology, Department of Internal Medicine, National Cheng Kung University Hospital, No. 138 Sheng-Li Road, Tainan 704, Taiwan. E-mail: lihsin@info.hosp.ncku.edu.tw This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 



 

Methods:

Several autoimmune diseases have been reported to be associated with common variable immunodeficiency disease (CVID), including rheumatoid arthritis and Sjögren's syndrome. On the other hand, approximately 20-30% of patients with rheumatoid arthritis develop secondary Sjögren's syndrome. A 26-year-old woman had a 6-year history of chronic symmetric polyarthritis and 3-year history of sicca syndrome prior to admission for pneumonia. Rheumatoid arthritis with secondary Sjögren's syndrome had been diagnosed 1 year before. The patient had experienced 3 episodes of pneumonia during the previous 3 years. Markedly depressed serum immunoglobulin levels prompted a suspicion of common variable immunodeficiency, and the impression was confirmed after a series of examinations. Monthly administration of intravenous immunoglobulin (IVIG) alleviated the polyarthritis and improved the sicca syndrome. IVIG replacement therapy was ultimately successful in curing recurrent bacterial infections, chronic polyarthritis, and improving the severity of sicca syndrome.

 



 

Key words:

Common variable immunodeficiency, intravenous immunoglobulins, rheumatoid arthritis, Sjögren's syndrome



 



 

J Microbiol Immunol Infect 2005;38:358-360.