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Volume 38, Number 5, October 2005

A retrospective study of hantavirus infection in Kinmen, Taiwan

Ling Chow, Pei-Yun Shu, Jyh-Hsiung Huang, Hsi-Chieh Wang, Shu-Fen Chang, Hsiu-Ying Lu, Ting-Hsiang Lin
Center for Research and Diagnostics, Center for Disease Control, Department of Health, Taipei, Taiwan>

Received: October 1, 2004    Revised: March 20, 2005    Accepted: May 21, 2005   


Corresponding author:

Dr. Ting-Hsiang Lin, Research Fellow, Center for Research and Diagnostics, Center for Disease Control, Department of Health, No. 161, Kun-Yang Street, Taipei 115, Taiwan. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it




In this retrospective study, 140 serum samples collected from 85 scrub typhus-negative patients in Kinmen Island in 2000 were tested for antibodies to hantavirus using enzyme-linked immunosorbent assay. Seven patients (8.23%) were confirmed as having hantavirus infection as demonstrated by increased hantavirus-specific immunoglobulin M and/or immunoglobulin G antibodies in their convalescent serum samples. Analysis of indirect immunofluorescence assay showed that Seoul type was the etiologic agent. Serosurvey of rodents caught in the resident township of these hantavirus-infected human cases showed that the seroprevalence of antibodies to hantavirus among Rattus norvegicus, Mus musculus, and R. flavipectus was 50% (4/8), 20% (1/5), and 2% (7/348), respectively. Molecular analysis showed that these reservoir hosts carried a Seoul type hantavirus. To our knowledge, this is the first report demonstrating indigenous hantavirus cases in Kinmen.



Key words:

Enzyme-linked immunosorbent assay, hantavirus, polymerase chain reaction, seroepidemiologic studies, Taiwan



J Microbiol Immunol Infect 2005;38:343-349.