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Volume 39, Number 2, April 2006

Osteomyelitis as a late complication of Bacille Calmette-Guérin vaccination

Ghamar Taj Khotaei, Leyla Sedighipour, Fatemeh Fattahi, Zahra Pourpak
Departments of Infectious Disease and Immunology, Asthma & Allergy Research Institute, Children Medical Center, Tehran University of Medical Sciences, Tehran, IR Iran

Received: August 24, 2005    Revised: October 1, 2005    Accepted: October 12, 2005   


Corresponding author:

Ghamar Taj Khotaei MD, Associate Professor of Pediatric Infectious Disease, Department of Infectious Disease, Children Medical Center, No. 62, Dr. Gharib St, Keshavarz Blvd, PO Box 14185-863, Tehran 14194, IR Iran. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it



Bacille Calmette-Guérin (BCG) osteomyelitis is a very rare complication of BCG vaccination. We report a 14-month-old boy who received BCG vaccination at birth. He developed pain and swelling in his left calf at 11 months of age. BCG osteomyelitis was diagnosed in right femur and left tibia. He had no evidence of immunodeficiency. After antituberculous therapy and surgical treatment, the bone lesions disappeared and he was discharged from hospital without any sequela during 11 months of follow-up.



Key words:

BCG vaccine, complications, Osteomyelitis



J Microbiol Immunol Infect 2006;39:169-172.