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Volume 39, Number 2, April 2006

Levels of intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with Henoch-Schönlein purpura


Ling-Jen Wang, Yao-Hsu Yang, Yu-Tsan Lin, Bor-Luen Chiang
Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei; and Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

Received: December 24, 2004    Revised: March 9, 2005    Accepted: March 14, 2005   

 

Corresponding author:

Dr. Bor-Luen Chiang, Department of Pediatrics, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei, Taiwan. E-mail: gicmbor@ha.mc.ntu.edu.tw This e-mail address is being protected from spam bots, you need JavaScript enabled to view it



 

Background and purpose: 

Henoch-Schönlein purpura (HSP) is a small vessel vasculitis. Soluble adhesion molecules play a very important role in the immuno-inflammatory reaction of damaged vascular tissues. This study investigated the prognostic and diagnostic potential of soluble intracellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in HSP.

 



 

Methods:

Serum levels of sICAM-1 and sVCAM-1 were studied in 26 children with HSP. Paired blood samples (during acute and convalescent stages) were collected from 17 of the children and assayed by enzyme-linked immunosorbent assay. Correlations with clinical manifestations were examined. Seventeen healthy children served as controls.

 



 

Results:

Both sICAM-1 and sVCAM-1 were significantly elevated at the acute stage compared with the remission stage of HSP patients versus controls (p=0.006 and p=0.0173, respectively).

 



 

Conclusion:

Although the levels of sICAM-1 and sVCAM-1 were not correlated with the severity of clinical manifestations in HSP, these soluble adhesion molecules may serve as diagnostic markers.

 



 

Key words:

Henoch-Schönlein purpura, intercellular adhesion molecule-1, vascular cell adhesion molecule-1

 



 

J Microbiol Immunol Infect 2006;39:109-113.