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Volume 39, Number 3, June 2006

Risk factors for central venous catheter-related infections in general surgery

Huan-Sheng Chen, Fu-Der Wang, Man Lin, Yi-Chun Lin, Ling-Ju Huang, Chen-Yi Liu
Department of Medicine, Li-Shin Hospital, Taoyuan; Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University of Medicine, Taipei; Department of Infection Control, Taipei Veterans General Hospital, Taipei; and Department of Medicine, Taichung Hospital, Department of Health, The Executive Yuan, Taipei, Taiwan

Received: May 17, 2004    Revised: November 30, 2004    Accepted: August 25, 2005   


Corresponding author:

Fu-Der Wang, Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it



Background and purpose: 

Central venous catheter (CVC) infection is a common problem during hospitalization and nosocomial bloodstream infection in these patients is associated with increased morbidity, mortality, and health care cost. This prospective study examined the risk factors of CVC-related infections.




During a 6-month period, a total of 281 patients who underwent central venous catheterization after general surgery were enrolled.




The mean duration from CVC insertion to the development of infection was 7.12 days. The rate of bloodstream infection without isolation of the same organism from the catheter was 1.4% (4/281). The rate of catheter-related bloodstream infection was 6.0% (17/281). The rate of catheter bacteremia, defined as positive culture from a catheter blood sample in a patient without signs of infection, was 8.5% (24/281). The incidence of catheter-related bloodstream infection was 7.5/1000 catheter-days. Risk factors for catheter-related infection on univariate analysis included place of insertion (operating room or surgical ward), total parenteral nutrition (TPN), more than 3 tubings, and duration of catheterization. TPN was a significant risk factor in the logistic regression analysis.




Established infection control guidelines should be rigorously observed with regard to catheter use and various risk factors controlled to prevent the occurrence of CVC-related infection, especially in patients receiving TPN.



Key words:

Bacteremia, central venous catheterization, infection control, risk factors, surgery



J Microbiol Immunol Infect 2006;39:231-236.