Print E-mail
Volume 39, Number 4, August 2006

Association between angiotensin-converting enzyme gene polymorphism and childhood allergic rhinitis in Taiwan


Min-Sho Ku, Ko-Huang Lue, Ching Li, Hai-Lun Sun, Ming-Chih Chou
Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung; and Institute of Medicine and Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan

Received: August 8, 2005    Revised: September 27, 2005    Accepted: October 8, 2005   

 

Corresponding author:

Dr Ko-Huang Lue, M.D., Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung 402, Taiwan. E-mail: cshy095@csh.org.tw



 

Background and purpose: 

Angiotensin-converting enzyme (ACE) play a role in inactivating bradykinin and tachykinins. Bradykinin and tachykinins are potent mediators of inflammatory reaction. An insertion/deletion polymorphism of the ACE gene has been shown to be associated with serum ACE levels. We hypothesized that ACE polymorphism might play a role in allergic rhinitis development.

 



 

Methods:

Seventy five children aged 6-13 years with atopic allergic rhinitis and 66 age- and gender-matched healthy children were studied. ACE genotypes were determined by polymerase chain reaction. Serum total immunoglobulin E (IgE) and allergen-specific IgE levels were also measured.

 



 

Results:

The frequencies of the DD and non-DD genotypes, and of the II and non-II genotypes did not differ significantly between healthy children and allergic rhinitis children (chi-squared test, p=1.000 and 0.438, respectively). There was no association of ACE genotype and mean IgE levels in rhinitis children or healthy controls.

 



 

Conclusion:

The results of our study indicate that polymorphism of the ACE gene is unrelated to the development of allergic rhinitis, the duration of allergic rhinitis, serum IgE levels, and allergen-specific IgE in Taiwanese children.

 



 

Key words:

Genetic polymorphism, genotype, peptidyl-dipeptidase A, perennial allergic rhinitis, Taiwan

 



 

J Microbiol Immunol Infect 2006;39:297-301.