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Volume 39, Number 5, October 2006

Bacteremia caused by Salmonella enterica serotype Choleraesuis in Taiwan


Shio-Shin Jean, Jen-Yu Wang, Po-Ren Hsueh
Departments of Internal Medicine and Intensive Care Medicine, Min-Sheng General Hospital, Taoyuan; Department of Internal Medicine, Cardinal Tien Hospital, Fu Jen Catholic University College of Medicine, Taipei; and Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

Received: June 1, 2006    Revised: June 13, 2006    Accepted: June 19, 2006   

 

Corresponding author:

Po-Ren Hsueh, Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. E-mail: hsporen@ha.mc.ntu.edu.tw This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 



 

Methods:

Since 1995, there has been a steady increase in the number of reported cases of Salmonella enterica serotype Choleraesuis (S. Choleraesuis) sepsis in Taiwan. Representative Taiwanese survey data from 1996 to 2004 revealed that these adult patients with S. Choleraesuis bacteremia presented with primary bacteremia (57%, especially immunocompromised hosts), mycotic aneurysm (16%), and fever (86%) predominantly. S. Choleraesuis septicemia demonstrated a higher invasion index (with secondary involved sites) than other Salmonella spp. In swine experiments, the inoculation dose of 103 colony forming units S. Choleraesuis was cleared without apparent sequelae. Transmission of specific strains (with mutations of GyrA and parC, subsequently resistance to fluoroquinolones) from swine, and the acquisition of genes (CMY-2, AmpC complex) encoding beta-lactamases (with resistance to extended-spectrum cephalosporins) have been implicated in the evolution of multiresistant phenotypes of S. Choleraesuis. The virulence plasmid of S. Choleraesuis (pSCV), and other genes mediating adhesion to the epithelial cell membrane of the gastrointestinal tract, were considered important pathogenic factors for S. Choleraesuis. Vaccines for domestic animals combined with effective controls on antibiotic use offer the greatest potential to control the increasing impact of S. Choleraesuis on humans.
 



 

Key words:

Beta-lactamases, cephalosporins, fluoroquinolones, Salmonella enterica, vaccines

 



 

J Microbiol Immunol Infect 2006;39:358-365.